diff --git a/Koha/Plugins/Handler.pm b/Koha/Plugins/Handler.pm
index 7d0e602a05..26dc1ed73a 100644
--- a/Koha/Plugins/Handler.pm
+++ b/Koha/Plugins/Handler.pm
@@ -19,8 +19,9 @@ package Koha::Plugins::Handler;
 
 use Modern::Perl;
 
-use Array::Utils qw( array_minus );
-use File::Path   qw( remove_tree );
+use Array::Utils    qw( array_minus );
+use File::Path      qw( remove_tree );
+use List::MoreUtils qw( any );
 
 use Module::Load qw( load );
 
@@ -69,6 +70,10 @@ sub run {
     if ($has_method) {
         load $plugin_class;
         my $plugin = $plugin_class->new( { cgi => $cgi, enable_plugins => $args->{'enable_plugins'} } );
+
+        my @management_methods = qw( enable disable install uninstall upgrade configure );
+        return unless ( $plugin->is_enabled || any { $plugin_method eq $_ } @management_methods );
+
         return $plugin->$plugin_method($params);
     } else {
         warn "Plugin does not have method $plugin_method";
diff --git a/t/db_dependent/Koha/Plugins/Plugins.t b/t/db_dependent/Koha/Plugins/Plugins.t
index 9988bfff14..66b057dd93 100755
--- a/t/db_dependent/Koha/Plugins/Plugins.t
+++ b/t/db_dependent/Koha/Plugins/Plugins.t
@@ -26,7 +26,7 @@ use List::MoreUtils           qw(none);
 use Module::Load::Conditional qw(can_load);
 use Test::MockModule;
 use Test::NoWarnings;
-use Test::More tests => 20;
+use Test::More tests => 21;
 use Test::Warn;
 use Test::Exception;
 
@@ -414,6 +414,45 @@ subtest 'Koha::Plugin::Test' => sub {
     $schema->storage->txn_rollback;
 };
 
+subtest 'Handler::run() skips disabled plugins' => sub {
+
+    plan tests => 5;
+
+    $schema->storage->txn_begin;
+
+    # Temporarily remove any installed plugins data
+    Koha::Plugins->RemovePlugins( { destructive => 1 } );
+
+    t::lib::Mocks::mock_config( 'enable_plugins', 1 );
+    my $plugins = Koha::Plugins->new( { enable_plugins => 1 } );
+    my @plugins;
+    warning_is { @plugins = $plugins->InstallPlugins; } undef;
+
+    # Enabled plugin runs successfully
+    my $plugin = Koha::Plugin::Test->new( { enable_plugins => 1, cgi => CGI->new } );
+    $plugin->enable;
+    is(
+        Koha::Plugins::Handler->run( { class => "Koha::Plugin::Test", method => 'report', enable_plugins => 1 } ),
+        "Koha::Plugin::Test::report", 'Handler::run() executes enabled plugin'
+    );
+
+    # Disabled plugin is skipped
+    $plugin->disable;
+    is(
+        Koha::Plugins::Handler->run( { class => "Koha::Plugin::Test", method => 'report', enable_plugins => 1 } ),
+        undef, 'Handler::run() returns undef for disabled plugin'
+    );
+
+    # Management methods still work on disabled plugins
+    $plugin = Koha::Plugin::Test->new( { enable_plugins => 1, cgi => CGI->new } );
+    ok( !$plugin->is_enabled, 'Plugin is still disabled after Handler::run skipped it' );
+    Koha::Plugins::Handler->run( { class => "Koha::Plugin::Test", method => 'enable', enable_plugins => 1 } );
+    $plugin = Koha::Plugin::Test->new( { enable_plugins => 1, cgi => CGI->new } );
+    ok( $plugin->is_enabled, 'Handler::run() allows enable method on disabled plugin' );
+
+    $schema->storage->txn_rollback;
+};
+
 subtest 'RemovePlugins' => sub {
     plan tests => 3;